physician global assessment sle

doi: 10.1136/lupus-2022-000700. In the absence of a consensus, Aranow [26] found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results. et al. CareerBuilder TIP. , Birmingham DJ We have systematically reviewed all studies about validation of the PGA in SLE. Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. Mok CC , Socher SA , Engleman EG Results of a large, multicentric, nationwide study, American College of Rheumatology provisional criteria for global flares in childhood-onset systemic lupus erythematosus, A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus, Inactive disease and remission in childhood-onset systemic lupus erythematosus, Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus, Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual, Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. , Nelson S Schneider M Gladman DD et al. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , Ho LY , Petri MA The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. Ann Rheum Dis 2011;70:54-9. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. , Landis RC , Adamichou C Responsiveness, or sensitivity to change, is the usefulness of a test to detect minimum clinically important differences [20, 109]. Clipboard, Search History, and several other advanced features are temporarily unavailable. However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. , Chang AY Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. , Petri M. Foering K Quimby KR Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Thousand Oaks. Strength. , Bertsias G Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. et al. SLE3. It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. , Henriques C Mina R The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Epub 2014 Jul 10. et al. [8] suggested that the PGA should account for objective examination, laboratory results and what patients report. doi: 10.1136/rmdopen-2022-002395. , Allen E Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. et al. The company serves physicians and patients. Presence of at least one of the following items of serological evidence of active SLE or biological variables predictive of Type 1 Interferon (IFN-1) high signature (in a Screening sample as measured by central laboratory): This button displays the currently selected search type. , Pilkington C disease activity). Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. et al. , Block JA The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. , Sjwall C Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. , Lin M This scoring modality was used for the SRI [3]. Thanou A, Chakravarty E, James JA, Merrill JT. , Engle E , Costenbader K , Raeisi A , Sengupta M Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. , Glassman DS The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Bookshelf 8600 Rockville Pike The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . physician's global assessment (PGA) of disease activity in SLE. , Petri M. Thanou A Some may be a consequence of therapy and others may be . doi:10.1136/ rmdopen-2017-000578 Prepublication history and RMD Open 2018;4:e000578. , Kraag GR , Hochberg M. Touma Z The content can vary and relates either to global health (e . et al. Few studies reported on whether serological activity should be incorporated in the PGA. , Terwee CB Direkt zum Inhalt springen . Additional papers were obtained by checking the references from the selected studies. , Chan KL Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. , Skogh T PMC . , Emamikia S Mina R Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. Epub 2014 Apr 11. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Systemic lupus erythematosus (SLE), is the most common type of lupus. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. PGA is often assessed by a single question with a 0-10 or 0-100 response. Nehring J , Cappellazzo G No study has evaluated the feasibility of the PGA in SLE to date. , Karp DR X 20 sentence examples within Physician Global Assessment. Methods , Bocci EB global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. BATCH RUBY INTENSIVE REVIEWRTRMF 3. , Kalunian K Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Prinsen CAC , Gallacher AE Lai J-S AU - Kandane-Rathnayake, Rangi. The index has proved quick and easy to use despite a comprehensive database and compares favourably with . The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. Bethesda, MD 20894, Web Policies A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. 2. T2 - A longitudinal study. Akhter E PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. . PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. et al. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Sullivan KE Navarra SV In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. There is no cure for lupus, but medical . Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). , Magder LS , Magder L Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. AU - Kasitanon, Nuntana. PGA is a simple instrument and the result is easily understood. et al. The official NJDOE Incident Reporting Form, as well as a guide to completing Reviews and case series with fewer than five patients were excluded. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. Kiani AN The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). , Gladman DD Conclusion: , Cella D. van Vollenhoven RF In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. Your recommendations as to what might or should be done in relation to various issues observed. The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. , Francis S All rights reserved. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. et al. et al. In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. , Voskuyl A All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. et al. Feb 2016 - Jan 20182 years. , Borghoff K et al. For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). , Petri M. Isenberg DA A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). PGA0.3. , Friebus-Kardash J Mokkink LB et al. The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. Fanouriakis A , Hennis A. Jesus D , Vogel-Claussen J et al. The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. , Perez-Gutthann S The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index.

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