how long does methimazole stay in your system after stopping

#4. For oral dosage form (tablets): For hyperthyroidism: AdultsAt first, 15 to 60 milligrams (mg) per day, given in 3 divided doses about every 8 hours. If you notice other effects not listed above, contact your doctor or pharmacist. Shouldnt hyperthyroid patients LOSE weight? Are there any warnings for people who handle Felimazole? One large in left lobe of 2.2. cm with vascularity. Hey There! The drug crosses the placenta and concentrates in the thyroid gland of the fetus. Also wear gloves when you handle broken or moistened Felimazole tablets. Another side effect that patients often experience when starting methimazole is weight gain. Methimazole For Cats Dosage. We will be scheduling the iodine treatment soon! Home Patients Portal Clinical Thyroidology for the Public Vol 7 Issue 4 Vol 7 Issue 4 p.12-13, CLINICAL THYROIDOLOGY FOR THE PUBLIC A publication of the American Thyroid Association, Summaries for the Public from Clinical Thyroidology (from recent articles in Clinical Thyroidology) Table of Contents | PDF File for Saving and Printing. Poor girl! Hyperthyroidism (Overactive): https://www.thyroid.org/hyperthyroidism/, Radioactive Iodine: https://www.thyroid.org/radioactive-iodine/, Thyroid Nodules: https://www.thyroid.org/thyroid-nodules/. Although not all of these side effects may occur, if they do occur they may need medical attention. This study suggests that long-term treatment with methimazole was safe and effective for normalizing the thyroid function in patients with a toxic nodular goiter with relatively few side effects. Check out my own personal health story. We call the normal thyroid state euthyroidism but you dont necessarily have to know that for the purposes of this article. Some products that may interact with this drug include: "blood thinners" (such as warfarin), digoxin. None of the patients in the continuous treatment group who were exposed to the other drug developed side effects, whereas 9 of 10 patients in the "gap" group exposed to the other drug developed minor side effects. Selected from data included with permission and copyrighted by First Databank, Inc. Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. Then later when I added supplements and my lab tests were improving very quickly, my new Endo would decrease my dose by no more than 2.5 mg at a time. FDA also encourages you to work with your veterinarian to report any adverse event - in either pets or people -associated with Felimazole or any product defect such as defective packaging or the drug is off-color. Ill see if she continues to vomit and if so, I'll give the vet a call. The drug is typically given by mouth every 12 hours. Methimazole doses are based on weight in children, and any changes may affect your child's dose. Good luck with your baby! Archives of Endocrinology and Metabolism. In cats, oral methimazole is rapidly absorbed, with: An oral bioavailability of 93% Maximal serum concentrations seen within 1.5 hours. We had to take him off the pills and get the gel for his ear in a lower dose, which we have not started yet due to him getting a cold. Take your next dose at the regular time. The researchers, from Imam Reza Hospital and other facilities in Mashhad, Iran, evaluated 151 patients with Graves' disease, ranging from 18 to 65 years old. It works by stopping the thyroid gland from making too much thyroid hormone. How to Report Animal Drug and Device Side Effects and Product Problems. Only one drug, Felimazole Coated Tablets (methimazole), is FDA-approved to treat hyperthyroidism in cats. Low-iodine diets are not generally advised for Graves' patients before RIT, agree Drs. While methimazole is definitely effective at stopping the hyperthyroid state and reducing the symptoms associated with hyperthyroidism, long-term methimazole use may cause some serious consequences. Does Methimazole interact with other medications? Long-term methimazole use may result in potential liver damage (4), changes to your bone structure (5), and more. Does Methimazole interact with other drugs you are taking? Check with your doctor immediately if any of the following side effects occur while taking methimazole: Some side effects of methimazole may occur that usually do not need medical attention. I'm very upset because I figure he's the doctor and shouldn't have left that choice up to me. Home Patients Portal Clinical Thyroidology for the Public September 2019 Vol 12 Issue 9 p.11-12, CLINICAL THYROIDOLOGY FOR THE PUBLIC We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. How to choose the right food for your cat. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Have they cleared up? As much as one-half of patients with hyperthyroidism will experience a relapse in their condition and no longer need it. She's been through it, hasn't she? She's finally starting to feel better but man, it's been rough! P.S. The researchers conclude that "Shorter discontinuation of methimazole before RIT may be preferable in most patients.". Properly discard this product when it is expired or no longer needed. For medicines, it can possibly take months. Can You Take A Z-Pak If You Have A Penicillin Allergy? Below Ive split up the types of symptoms you may experience from methimazole into 3 different groups. These side effects may go away during treatment as your body adjusts to the medicine. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. Even while taking methimazole you can take advantage of natural therapies such as improving your diet, avoiding gluten, reducing your stress, and taking supplements to help put your hyperthyroidism into remission. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The drug is also found in breast milk. Aplasia cutis congenita has been reported as a possible teratogenic effect of methimazole therapy in multiple case reports. He gave us anti nausea meds but she was so nauseous, she couldn't even keep them down. Maintenance dose: 5 to 15 mg orally per day. itchy skin, especially the face, head, and neck. Keep all medications away from children and pets. Dizziness. "Definitely, this looks like a cure of the disease if we consider this very low incidence of relapse," he commented. This is what vets and online reasearch told me. If metronidazole is causing side effects, such as nausea, diarrhea, or vomiting, you can expect them to resolve a few hours after dosing, or at the very latest, within a few days after the last dose was taken. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Learn which foods you should avoid if you have thyroid disease of any type. The problem here is that slowing down thyroid function isnt a perfect science so its easy to slow down thyroid function too much. Objective: To investigate the long-term effects of continuous methimazole (MMI) therapy. Consult your doctor before breast-feeding. On closer inspection, several of the latter patients were excluded because they did not fit the criteria for the study, leaving 14 patients with interrupted treatment. My HR wakes me up at 100-120, I feel hot. Once the excessive level of thyroid hormones is lowered by Felimazole (or any treatment for hyperthyroidism), the blood flow to the kidneys returns to normal and the kidney function in some cats will worsen. About 90% of radiolabeled letrozole is recovered in urine. Unfortunately, it can be very difficult to try and lose weight while you are taking methimazole. You can read more about my own personal health journey and why I am so passionate about what I do. For a better experience, please enable JavaScript in your browser before proceeding. This medicine is available only with your doctor's prescription. Therefore it is essential to note the maximally allowed dosage. Want to know why I'm so passionate about these topics? Before sharing sensitive information, make sure you're on a federal government site. Patients with Graves disease were excluded. 2 days on, one day off and this past week my endocrinologist gave me the choice of either going right off Tapazole or going off it slowly. Propylthiouracil is used to treat hyperthyroidism, especially in women during pregnancy. Methimazole, the active ingredient in Felimazole, is an antithyroid drug that works by blocking the production of thyroid hormones. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). When the thyroid gland produces an excessive amount of thyroid hormones, it causes the cats engine to run at an abnormally high speed. "What happens after the year would be important to look at,'' he says. A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, HYPERTHYROIDISM Although the study provides some important information, the study follow up is brief, Dr. Wexler pointed out. Toward the end of the month he started throwing up white foam and sometimes his food. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. The usual recommended duration of therapy is somewhere around 18 to 24 months. Metronidazole is mostly metabolized in the liver and is excreted via the urine and feces. Things to remember when you fill your prescription. She presented with hairless scars on her scalp. and I'm proud to say that over 80,000+ people have used them over the last 6 years. A change in appetite (the cats appetite may increase or decrease). Epub 2019. For starters, how about the fact that it can have some serious consequences on your liver? Within one year after discontinuation of MMI, hyperthyroidism recurred in 104 patients. Paxil is one of the strongest ssris and hardest to get off of but remember your symptoms of anxiety etc were developing as you were on these pills so whatever you're feeling right now shouldn't be blamed or pinned as outright withdrawl. This site complies with the HONcode standard for trustworthy health information: verify here. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. For the Depo shot, the half-life is 200-250 days . MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. They discontinued the medication one to two days before, or just over two days to three days, or just over three days to a week before. However, methimazole has been shown to be safe for long term use in patients with Graves disease. "In our practice, we usually discontinue methimazole for 48 hours before radioiodine use with good results," he says. In cats with hyperthyroidism, the high level of thyroid hormonesincreasesthe blood flow to the kidneys, which helps their kidneys and may even hide kidney disease. In this way, methimazole is really just used as a way to blunt the serious side effects of hyperthyroidism while giving your body time to fix whatever caused the hyperthyroid state to begin with. Hyperthyroidism often leads to high blood pressure (hypertension) and heart disease. Its the most common endocrine disease of cats older than 8-years-old. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away. 12 Medicines That Could Help, List Methimazole side effects by likelihood and severity. Discuss the risks and benefits with your doctor. Methimazole is an antithyroid medicine. Tapazole (methimazole)." Because methimazole BLOCKS thyroid function you can expect it to have consequences that impact your thyroid. The whole purpose of using methimazole is to slow down your thyroid to take you out of the hyperthyroid state. That study is published online September 25 in Archives of Endocrinology and Metabolism. For the past year, I had been in remission, and placed on a maintenance dose of 5mg Methimazole. Do not store in the bathroom. It is also used before thyroid surgery or radioactive iodine treatment. In RIT, the thyroid gland tissue is shrunk or destroyed. Almost three weeks ago here were my labs: TSH [L] <0.01 uIU/mL [0.30-4.70] Free T4 1.89 ng/dL [0.75-2.00] FT3 [H] 5.5 pg/mL [2.3-4.2] I'm on 10mg of methimazole which I take as 5mg twice a day. The most common side effects of Felimazole reported to FDAs Center for Veterinary Medicine are: FDA encourages you to call your veterinarian if you think your cat is having aside effect from Felimazole. Hey! The researchers found no differences in how well the RIT worked six months later. I love to write and share what I've learned over the years. Hyperthyroidism may be treated with antithyroid meds (Methimazole, Propylthiouracil), radioactive iodine or surgery. Other common signs include vomiting, diarrhea, hyperactivity, drinking and urinating more than normal, and an unkempt hair coat. a nutrition B-12 deficiency. Can You Get Everything Your Thyroid Needs From Food? The dose is then titrated/adjusted depending on recheck lab work after three weeks. Use this medication regularly to get the most benefit from it. This medication passes into breast milk. Veterinarians had to rely on methimazole products approved for people, which they prescribed in an extra-label manner in cats. They also may allow you to get off of methimazole sooner rather than later (which would be ideal for most people). Radioactive iodine: this plays a valuable role in diagnosing and treating thyroid problems since it is taken up only by the thyroid gland. Once we have antibodies, we have them for life, although TSI (thyroid stimulating immunoglobulin), the antibody associated with Graves', often goes into remission. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Moderately severe hyperthyroidism: 30 to 40 mg orally per day. Methimazole is used to treat hyperthyroidism, especially when it is caused by Graves' disease. Per the label for the FDA-approved product Felimazole for cats, the dose for methimazole starts at 2.5 milligrams per cat every 12 hours. Using this strategy anywhere from 15 to 50% of patients may experience a relapse in their hyperthyroid symptoms and no longer need any therapy to treat their hyperthyroidism. Design and methods: Five hundred and four patients over 40 years of age with diffuse toxic goiter were treated with MMI for 18 months. She may have irritated her tummy vomiting and that is causing more vomiting. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. If you miss a dose, take it as soon as you remember. The new research is important, agrees Spyros Mezitis, MD, PhD, an endocrinologist at Lenox Hill Hospital in New York who also reviewed the findings. I-123 is the non-destructive form that does not damage the thyroid and is used in scans to take pictures of the thyroid (Thyroid Scan) or to take pictures of the whole body to look for thyroid cancer (Whole Body Scan). Hashimotos vs Graves Disease: Differences & Similarities, What is Graves Disease? If you accidentally ingest Felimazole, call your healthcare provider immediately and show the drugs label to the provider. And these natural therapies are incredibly safe and they are things that you are able to do on your own. They received methimazole therapy (for 5 to 8 years) or receive treatment with radioactive iodine therapy. Hyperthyroidism: http://www.thyroid.org/what-is-hyperthyroidism, Graves disease: http://www.thyroid.org/what-is-graves-disease, Table of Contents | PDF File for Saving and Printing, A publication of the American Thyroid Association. However, when accounting for the +/- 2 hour variability of its half-life, some people may excrete the drug in just 16.5 hours, while others may take nearly 2 days (1.6 days) to completely excrete it. But what you should know is that its incredibly difficult for your doctor to take you from the hyperthyroid state to the normal thyroid state with methimazole. When there arent enough neutrophils in the blood, the cat is at greater risk for developing a dangerous infection. This strategy requires a much smaller dose of methimazole but patients may have to take it for 60 to 120 months (3) (5 to 10 years). Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. If you are one of them, you need to be aware of the potential side effects and consequences of this medication. The FDA-approved brand name product Felimazole ( methimazole) is a tablet given by mouth. I still struggle with what to do with the ones that are way out there. The medication methimazole works by preventing the thyroid gland from making too much thyroid hormone. Regularly checking blood tests and urine samples will help monitor for signs of kidney disease. How are the facial itching and the hive beneath her nose? She has not had any in about a day and a half but she is still vomiting. Methimazole in a transdermal gel or cream that you could rub on your cat's ear's interior side. However, the intrathyroidal residence of methimazole is roughly 20 hours, and the duration of action 40 hours, which allows once-daily dosing some patients. Methimazole therapy may be a viable and safe option for the treatment of toxic goiters over the long term. Available at http://online.liebertpub.com/doi/abs/10.1089/thy.2013.0476. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Patients had a diagnosis of hyperthyroidism confirmed with thyroid function tests. Now, researchers from Iran report that responses to the RIT were the same regardless of whether patients stopped their medication one to two days before or for a longer period, even up to four days before. For years, there was no methimazole product approved to treat hyperthyroidism in cats in the United States. Simply so, how long does methimazole stay in a cat's system? These therapies are very safe and can be very effective. The mechanism isnt that complicated either, it has everything to do with your thyroid. Plus my cat had hives that took about 8 weeks to start really clearing up after we stopped the medicine and eating chicken. What Every Hyperthyroid Patient Should Know, read more about my own personal health journey, free thyroid downloads, resources, and PDFs here, 3 New Thyroid Support Supplements: Thyro Fuel, Thyro Biotic & Hashimotos Ab Rx, The 50 mcg Levothyroxine & Synthroid Medication Hack. She writes for a variety of health websites and print publications, including EndocrineWeb, WebMD, OnTrackDiabetes, Senior Planet, Practical Pain Management, and others. We had to take her in for anti nausea injection meds. yellow eyes or skin. The medication can be given life-long or to stabilize the cat before other treatment options, such as radioactive iodine therapy or surgery. In almost 99 percent of the cases, hyperthyroidism is caused by a benign (non-cancerous) tumor of the thyroid gland. [Ref], Very rare (less than 0.01%): Nephritis[Ref], Frequency not reported: Insulin autoimmune syndrome, Frequency not reported: Vertigo, drug fever[Ref]. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. She was absolutely miserable. The use of alcohol and metronidazole together can cause a "Disulfiram-like" reaction. Initial dose: Mild hyperthyroidism: 15 mg orally per day. Many people using this medication do not have serious side effects. So where does methimazole fit in? [Ref], Frequency not reported: Lupus-like syndrome[Ref], Frequency not reported: Jaundice, hepatitis[Ref], Frequency not reported: Edema, periarteritis, A 5-year-old female experienced aplasia cutis congenita coincident with in utero exposure to methimazole. Home & Forums | She should slowly continue to improve. This medication is not recommended for use during the first 3 months of pregnancy. Raiu How are your feeling now? These types of therapies are often overlooked by conventional doctors even though they are highly effective. This is commonly associated with a fever and/or a sore throat. Kobayashi S et al. Withholding the medicine for more than three days, he says, may cause a worsening of the hyperthyroidism. It works by making it harder for the body to make thyroid hormone. If you are experiencing any of these side effects then you can talk to your doctor about making changes to your dose. How to Report Animal Drug and Device Side Effects and Product Problems. If you experience ANY of the side effects then you need to talk to your doctor immediately. Most cases of agranulocytosis occur within the first 90 days of treatment, but this complication can occur even a year or more after starting therapy. Welcome to my website! The rate of relapse at 48 months after stopping methimazole was 51% among patients in the short-term therapy group but just 16% among patients in the long-term therapy group (P less than or equal to .001). Methimazole is an antithyroid medicine. Thats what we had to do with our cat when she couldnt keep the oral nausea meds down. The shot. We comply with the HONcode standard for trustworthy health information. Im not a fan of this approach and I will provide some reasons why it may not be the best option below. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Thyroid. For cats with hyperthyroid . It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Didn't find the answer you were looking for? If so, which ones? I'm Dr. Westin Childs. Your doctor may direct you to use another medication during that time. Less common is a toxic nodular goiter, where one or more thyroid nodules are overactive and the rest of the gland is turned off. Unlike the methimazole products for people, Felimazole has been shown to be safe and effective in cats when used according to the directions on the label. If so, what type of side effects are you experiencing? You dont need permission from your doctor to eat more fruits and vegetables, avoid grains such as gluten, and make sure you sleep 8 hours per day. What are the signs of hyperthyroidism in cats? This content does not have an Arabic version. "Product Information. Long-term methimazole is an effective treatment for toxic nodular goiters. Answered by Dr. Brian Staiger, PharmD If metronidazole is causing side effects, such as nausea, diarrhea, or vomiting, you can expect them to resolve a few hours after dosing, or at the very latest, within a few days after the last dose was taken. Storage temperature ranges differ according to different manufacturers, so consult your pharmacist for more information. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Potential side effects include: Generally, it is recommended to avoid alcohol and alcohol-containing products (e.g cough medications with alcohol) during and for up to 3 days after the last dose of metronidazole. The site is secure. This resource is dedicated to helping people with thyroid problems, hormone imbalances, and weight loss problems get the help that they need. Further studies are needed to look at other outcomes such as impact on the quality of life and the cost of therapies. Increased risk of infection. Update: I saw my endo this week, and now he's asking me to consider radioactive iodine (RAI) because the lab work (the one with the result I've posted above, done in the beginning of August) shows that I have low white blood cell count, which might be due to methimazole. It would be great if you could update us on your condition. Some of the more frequently reported adverse reactions have included skin rash, urticaria, nausea, loss of taste, and abnormal loss of hair. How are the facial itching and the hive beneath her nose? TheCatSite.com participates in select affiliate advertising programs, including the Amazon Services LLC Associates Program. To determine how long Prednisone stays in your system after stopping, it is important to consider its half-life. Staff, Alternatives To Valtrex For The Treatment Of Herpes, Spearmint - Potassium Phosphate, Sodium Phosphate (prescription Drug), Cassia Auriculata - Botulinum Toxin Type A, Securinega Suffruticosa - Docusate Sodium, Phenolphthalein, Sonoma Diet - Capsaicin (prescription Drug), Yoga - Acetaminophen, Phenylpropanolamine, Rice Protein - Hydrochlorothiazide, Labetalol. Weight loss is average as long as it is not excessive. Graves' patients can be assured, Dr. Wexler says, that they would not get enough iodine from a typical, regular diet to interfere with RIT treatment. Also talk to your veterinarian about monitoring your cats blood pressure. After being off the thyroid meds, It took over a week and a half to see improvement. These side effects come from organ damage. This document does not contain all possible drug interactions. Methimazole: an antithyroid medication that blocks the thyroid from making thyroid hormone. When clicking a link here and buying, we may be able to make a small commission, at no additional cost to you. Toxic nodular goiter: characterized by one or more nodules or lumps in the thyroid that may gradually grow and increase their activity so that the total output of thyroid hormone in the blood is greater than normal. Long-term therapy with methimazole is not usually considered in treating patients with a toxic nodular goiter since this will never go into remission. The mechanism is not completely understood, but the presentation suggests an immunological mechanism. In our latest question and answer, the pharmacist discusses how long Flagyl (metronidazole) lasts in the body. Its really rough waiting for the thyroid meds to leave their system. TSH was 0.45. t3 and T4 normal. drug of choice to treat pretty much any hyperthyroid condition, your metabolism will be decreased and you will GAIN weight, 16 Foods Naturally High in Iodine Boost your Thyroid with Foods, 16 Hilarious Thyroid Memes That You Will Relate To, Add Back Therapy for Graves & Hyperthyroidism: When to use Levothyroxine, Hashimotos and Hyperthyroidism: Why it Happens & What it Means, How to Prevent Thyroid Surgery and Radioactive Iodine Ablation Therapy | Dr. Osansky and Dr. Childs. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. How long does methimazole stay in your system after stopping? how long for methimazole to work? Tell your doctor right away if you have any serious side effects, including: joint/muscle pain, numb/tingling skin, shortness of breath, coughing up blood, signs of liver problems (such as nausea/vomiting that doesn't stop, yellowing eyes/skin, dark urine, severe stomach/abdominal pain), signs of kidney problems (such as change in the amount of urine, bloody urine). Common facet consequences of metformin are : digestive issues, which includes diarrhea, vomiting, and flatulence. Metronidazole is metabolized and eliminated from the body completely around 2 to 3 days after your last dose. Dosage is based on your medical condition and response to . Reference ranges vary lab to lab. severely low level of neutrophils in the bloodneutrophils, a type of white blood cell, are part of the bodys immune system. To compensate for this increased workload, the muscles of the heart thicken, causing the heart to enlarge and eventually fail. Constipation. After excluding patients with other possible causes, 67 patients were identified as having MMI or PTU-induced agranulocytosis. In Canada - Call your doctor for medical advice about side effects. This is not a complete list of possible side effects. Methimazole is a reason for the increasing weight of patients during hyperthyroidism treatment. So it is VERY possible that you can have hyperthyroidism but be treated with methimazole AND gain weight. The vet told us to take her off immediately. It works by making it harder for the body to make thyroid hormone. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Methimazole is used to treat overactive thyroid (hyperthyroidism). Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, http://www.thyroid.org/what-is-hyperthyroidism, http://www.thyroid.org/what-is-graves-disease, Clinical Thyroidology for the Public (CTFP). I found out about my hyperthyroidism at the end of 2013, and confirmed Graves Disease in mid-2014 by iodine uptake scan. The antithyroid drugs methimazole (MMI) and propylthiouracil (PTU) are used as one option to treat patients with hyperthyroidism, especially those with Graves' disease. In the US - Call your doctor for medical advice about side effects.

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